Research opens up new directions to develop drugs for stopping cytokine storms
Constant exposure of cells to stressing agents, such as pathogens, may disturb an organism's normal functioning. To fight stress, cells have developed several coping mechanisms, including the...
View ArticleScientists unravel secrets about the formation of DNA's building blocks
An international team has uncovered details about the formation of DNA's building blocks, paving the way for potential medical and therapeutic applications.
View ArticleScientists uncover key enzymes involved in bacterial pathogenicity
Gram-negative bacteria cause a variety of infectious diseases in plants and animals alike. Outbreaks of Salmonella and E. coli infections often make headlines due to their severity, and people have to...
View ArticleCOVID Moonshot Consortium makes major breakthrough in antiviral drug discovery
The work of the COVID Moonshot Consortium is being published in the prestigious journal Science on 10 November, revealing their discovery of a potent SARS-CoV-2 antiviral lead compound.
View ArticleRevolution by Evolution: Protein Science and its Impact on Drug Discovery
In this interview conducted at SLAS EU 2023 in Brussels, Belgium, we spoke to Mark Abbott, the Managing Director of Peak Proteins, about protein science and its significance in drug discovery.
View ArticleOpen-science triumph: Crowdsourced initiative yields potent SARS-CoV-2...
In this study, researchers harnessed crowdsourcing and open science to develop new antivirals against SARS-CoV-2, focusing on its main protease, Mpro. Their approach led to the discovery of potent...
View ArticleNew insights into the structures formed during antibody aggregation through...
Antibodies (immunoglobulins) are Y-shaped proteins that recognize and neutralize specific pathogens. Their ability to target specific molecules or cells has made them promising candidates for future...
View ArticleNovel adaptations and functions of human LINE-1 revealed by structural...
Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding...
View ArticleDisease-causing bacteria use molecular "barcode" to distinguish between...
Researchers at McMaster University have discovered a molecular "barcode" system used by disease-causing bacteria to distinguish between beneficial and toxic molecules.
View ArticleUnlocking protein secrets: X-ray crystallography reveals hidden shapes
Proteins do the heavy lifting of performing biochemical functions in our bodies by binding to metabolites or other proteins to complete tasks.
View ArticleUB research may offer a more streamlined approach to developing cancer drugs
Drug discovery can be a frustrating process of trial and error.
View ArticleDeciphering the role of GPCRs in obesity pathology for drug development
Announcing a new publication for Acta Materia Medica journal. G protein-coupled receptors (GPCRs) are important, potential drug targets for the treatment of metabolic disorders, such as obesity.
View ArticleLAG-3 protein structure may be the key to unlocking new cancer treatments
A molecular “snapshot” of a protein can be critical to understanding its function. Scientists at Stanford and NYU have published and investigated a new structure of the protein LAG-3 which could enable...
View ArticleNIH study uncovers vulnerable sites on Epstein-Barr virus protein
Studies of interactions between two lab-generated monoclonal antibodies (mAbs) and an essential Epstein-Barr virus (EBV) protein have uncovered targets that could be exploited in designing treatments...
View ArticleNew drug candidate designed at the atomic level could help halt emerging...
Although COVID-19 has faded from the headlines, SARS-CoV-2 – the coronavirus behind the pandemic – is still rampantly infecting people around the world.
View ArticleNew drug candidates show promise to reverse HIV immune evasion
University of Pittsburgh School of Medicine scientists have identified drug candidates that show promise to reverse the ability of HIV to escape detection by the immune system.
View ArticleResearchers identify viable vaccine targets for hepatitis C infections
By studying individuals who spontaneously clear hepatitis C infections, a team of researchers has identified viable vaccine targets for a disease that infects 70 million worldwide with case numbers...
View ArticleAtomic-level structural models of enzymes provide disease insights
When nucleic acids like DNA or RNA build up in a cell's cytoplasm, it sets off an alarm call for the immune system.
View ArticleStudy reveals deadly bacteria's attraction to human blood
Some of the world's deadliest bacteria seek out and feed on human blood, a newly-discovered phenomenon researchers are calling "bacterial vampirism."
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